Explore our expansive portfolio of human platelet lysate cell culture supplements for a variety of research and cell therapy applications.
We offer a range of RUO and GMP-grade products along with heparin-required or fibrinogen-depleted options. Learn more below.
Over the last several years, human platelet lysate (HPL) has emerged as a superior alternative to fetal bovine serum (FBS) for cell therapy and regenerative medicine applications. As a growth factor-rich, xeno-free media supplement, HPL enables the rapid cell growth and expansion of various types of cells including MSCs and T-cells.
For those looking for a safe, consistent, and efficient culture system – Captivate Bio’s portfolio of human platelet lysate is a suitable and more cost-effective cGMP alternative to fetal bovine serum and some serum-free cell culture media.
Manufactured under cGMP in ISO-certified facilities. Release testing is conducted on every lot of HPL to ensure minimal lot-to-lot variation. HPL has a US FDA Master File on record.
Supports a wide range of cell types including MSCs, T-Cells, NK Cells, Endothelial cells, and more. Excellent supplement for cell expansion using large bioreactors.
Accelerates cell proliferation, leading to faster results with less supplementation(5% vol/vol) making HPL more cost effective compared to FBS or serum-free media.
Trusted globally, Captivate Bio offers one of the largest portfolios of Human Platelet Lysate (hPL) products to the stem cell and therapeutic research communities. We’ve recently expanded access of our HPL products to include the PLTGold® and PLTMax® brands as well as fibrinogen-depleted PLUS™ Human Platelet Lysate. Our team has been working closely with the original manufacturers for years to expand the utility of HPL as a reliable cell culture media supplement and make recommendations on the best path forward depending on your workflow and goals.
PLTMax HPL requires heparin in order to minimize coagulation and may be required for certain applications. PLTGold HPL or PLUS HPL does not contain or require heparin.
Over the last several years, human platelet lysate (hPL) has emerged as a proven, superior substitute for fetal bovine serum in various research applications including those working with MSCs, ESCs, iPSCs, T cells, NK cells and more. hPL is made from expired human platelets and collected at AABB & FDA certified blood banks. The below product recommendation chart is provided as a guide only.
HPL has been shown to be a superior alternative to FBS and human AB serum for the growth of MSCs and endothelial cells, currently being used in hundreds of clinical trials worldwide.
HPL shown to be suitable for suspension culture of T cells, facilitating the potential large-scale expansion in suspension of allogeneic CAR-T cells.
Expansion of T cells using PLTGold®-GI in comparison to 4 heparin-free competitor HPLS during 5 days of culture. PLTGold demonstrated a significantly faster and higher cell growth.
PUBLICATION SPOTLIGHT
Fetal bovine serum (FBS) has been used to support the growth and proliferation of mammalian cells for decades. Several trials have been conducted to evaluate substitutes to FBS including this study reviewing human platelet lysate as an alternative for cell therapy applications.
Mohamed et al. The Korean Journal of Hematology. 2020. Blood Res 2020; 55(1): 35-43.
This Research Spotlight highlights T cell expansion and the use of gamma irradiated human platelet lysate for use in bioprocessing and T cell and CAR-T manufacturing workflows.
This Research Spotlight takes a look at a study in Scientific Reports where researchers compare six commercially available media in the growth and expansion of BM-MSCs. Two media are found to rise to the top.
It’s never too early to plan the transition from research to clinical grade reagents, especially with human platelet lysate. This guide provides tips for moving your research from RUO to GMP supplements.
