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Small Molecules

Small Molecules

A growing number of small molecules have been identified to maintain the self-renewal potential of stem cells, to induce lineage differentiation, facilitate cellular reprogramming, and support cell cryopreservation across a wide range of applications including 3D modeling as well as cancer, diabetes, neuronal, and cardiovascular research.

Captivate Bio’s portfolio of small molecules for stem cell research are powerful tools capable of modulating and fine-tuning key pathways and targets within a cell. All our small molecules are rigorously tested by liquid chromatography and mass spectrometry as well as third-party validated to guarantee highest purities and chemical structure consistency.

Captivate Bio small molecules for hpsc stem cell research
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Captivate Bio's CET Cocktail Kit

Minimize cellular stress with Captivate Bio’s CET Cocktail

Captivate Bio’s CET Cocktail Kit is comprised of the small molecules used in the CEPT method: Chroman 1, Emricasan, and Trans-IRIB (CET). As the first to market, the CET Cocktail Kit enhances stem cell survival and address the key challenges in cell recovery.

The CET Cocktail Kit can be used for routine long-term passaging, cryopreservation, single-cell cloning, and organoid formation.

Explore the CET Cocktail

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  1. A83-01
    A83-01
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    A83-01 s a potent inhibitor of TGF-β type I receptor ALK5 kinase, type I activin/nodal receptor. A83-01 molecule facilitates stem cell reprogramming and differentiation of hPSCs. A83-01 is supplied as a lyophilized powder.
  2. BIRB796 (Doramapimod)
    BIRB796 (Doramapimod)
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    BIRB796 is a highly potent inhibitor of p38 MAPK that enhances stem cell activity of cultured umbilical cord blood-derived hematopoietic cells. BIRB796 can be used in protocols for the chemical reprogramming of somatic cells to iPSCs.
  3. CET Cocktail Kit includes Chroman 1, Emricasan, and Trans-ISRIB
    CET Cocktail
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    The CET Cocktail is comprised of the small molecule components in the CEPT cocktail: Chroman 1, Emricasan, and Trans-IRIB (CET). Enhances cell survival and promotes clonal growth of genetically stable hPSCs.
    Size: 1 Kit
  4. CHIR99021 Small Molecule
    CHIR99021
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    CHIR99201 potentiates self-renewal of human and mouse embryonic stem cells and enhances reprogramming of somatic cells into stem cells. CHIR99201 also augments the differentiation potential of mesenchymal stem cells.
  10. IWP-2 Small Molecule
    IWP-2
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    IWP 2 is a potent inhibitor of Wnt processing and secretion (IC50 = 27nM). IWP 2 inactivates PORCN, a membrane-bound O-acyltransferase (MBOAT), and selectively inhibits palmitoylation of Wnt. IWP-2 has also been used in protocols to reprogram somatic cells to chemically-induced PSCs.
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Custom Reagent Sourcing

If you can’t find what you need on our website, our team can help identify and deliver unique small molecules, cytokines, and growth factors that meet your requirements, timeline, and budget. Let Captivate Bio be your first stop in providing access to thousands of research and GMP grade reagents.

Contact our team today to get started.

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