Skip to the beginning of the images gallery

IWP-2

IWP 2 is a potent inhibitor of Wnt processing and secretion (IC50 = 27nM). IWP 2 inactivates PORCN, a membrane-bound O-acyltransferase (MBOAT), and selectively inhibits palmitoylation of Wnt. IWP-2 has also been used in protocols to reprogram somatic cells to chemically-induced PSCs.

Simple product items
SKU	SIZE	PRICE	QTY
SML03B	10 mg	$125.00	Qty - +

Request a Custom or Bulk Order

Details

Resources

Reviews

Description

Specifications

More Information
SKU	SML03B
Size	10 mg
Molecular Name	IWP-2
Size	10 mg
Form	Powder
Alternative Names	IWP 2, Inhibitor of WNT Production-2
Chemical Name	Acetamide, N-(6-methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3- phenylthieno[3,2-d]pyrimidin-2-yl)thio]-
Chemical Formula	C₂₂H₁₈N₄O₂S₃
Molecular Weight	466.60
CAS Number	686770-61-6
Purity	Greater than 95% by NMR
Physical Appearance	White to off-white (Solid)
Target	Porcupine (PORCN)
Shelf-Life	≥ 2 years (powder)
Shipping	Room Temperature
Storage	Store at -20°C
Quality Statement	This product is for Research Use Only and is not intended for therapeutic or diagnostic use.

Small Molecules for Stem Cell Research

IWP-2 is an inhibitor of the Wnt pathway, specifically targeting membrane-bound O-acyltransferase porcupine (PORCN) with an IC50 of 27 nM. This inhibition, in turn, prevents Wnt activation, secretion, and signaling (Garcia-Reyes, et al.), which leads to decreased self-renewal of human embryonic stem cells (ESCs) (Kim, et al). IWP-2 has been an effective component within differentiation protocols of pluripotent stem cells (PSCs) into functional cardiomyocytes when combined with CHIR99021, IWP-4, Activin A, bFGF, and BMP4 (Lian, et al.). Additionally, IWP-2 shows promise in the differentiation of iPSCs into corneal epithelial cells (Mikhailova, et al.).

Resources

Documents

References and Publications

Garcia-Reyes, et al. 2018. Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds as Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1). J Med Chem 61(9): 4087-4102.
Mikhailova, et al. 2014. Small-molecule induction promotes corneal epithelial cell differentiation from human induced pluripotent stem cells. Stem Cell Reports. 2(2): 219-231.
Kim, et al. 2013. Modulation of β-catenin function maintains mouse epiblast stem cell and human embryonic stem cell self-renewal. Nature Communications. 4(2403).
Lian, et al. 2013. Directed cardiomyocyte differentiation from human pluripotent stem cells by modulating Wnt/β-catenin signaling under fully defined conditions. Nature Protocols 8(1): 162-175.

Reviews

Write Your Own Review

Other Resources

Cell Culture Guides

eBook Download: Preventing Mycoplasma Contamination

Download this free eBook from Captivate Bio. We’ve compiled information over the years to help you build on a lab program designed to fit your own needs.

Brochures

Small Molecules for Cell Therapy Flyer

PDF | Download our Small Molecules for Cell and Gene Therapy Research flyer. Now offering RUO and GMP-grade small molecules for a variety of cell types.

Brochures

The Captivate Bio Access Program Flyer

PDF | Download The Captivate Bio Access Program flyer and learn more about how we can support small and mid-size life science companies who are looking for immediate access to consulting, marketing, and sales programs.