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Retinoic Acid

Retinoic Acid is a metabolite of vitamin A that acts as a ligand for nuclear retinoic acid receptors. Retinoic acid has been used for the differentiation of embryonic stem cells into motor neurons and has also played an important role in protocols involving the differentiation of human pluripotent stem cells (PSCs) into functional pancreatic β cells.

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SKU	SIZE	PRICE	QTY
SML07F	500 mg	$85.00	Qty - +

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SKU	SML07F
Size	500 mg
Molecular Name	Retinoic Acid
Size	500 mg
Form	Powder
Alternative Names	Retinoic acid (AT), Retinoic acid (All-trans), All-trans retinoic acid (ATRA), NSC 122758, Trans retinoic acid, Tretinoin, Vitamin A acid, RA
Chemical Name	(all-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid
Chemical Formula	C₂₀H₂₈O₂
Molecular Weight	300.44
CAS Number	302-79-4
Purity	Greater than 95% by LCMS
Physical Appearance	Light yellow to yellow (Solid)
Target	RAR/RXR; PPAR; Endogenous Metabolite
Shelf-Life	≥ 2 years (powder)
Shipping	Room Temperature
Storage	Store at -20°C sealed, to protect from light and moisture
Quality Statement	This product is for Research Use Only and is not intended for therapeutic or diagnostic use.

Small Molecules for Stem Cell Research

Retinoic Acid (all-trans) is a metabolite of vitamin A that acts as a ligand for nuclear retinoic acid receptors (RARs, specifically RARα/β/γ) with an IC50 of 14nM and has a major effect on the differentiation and patterning of stem cells, and therefore in the development process (Rhinn & Dolle). In the process of differentiating mouse embryonic stem cells (ESCs), Retinoic Acid has been shown to promote the growth of glial cells and functional neurons in culture (Fraichard, et al.).

Furthermore, Retinoic Acid has played an important role in protocols involving the differentiation of human pluripotent stem cells (PSCs) into functional pancreatic β cells when combined with CHIR99021, SANT-1, Y27632, Compound E, RepSox, Triiodothyronine Salt, and other growth factors (Pagliuca, et al.).

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References and Publications

Pagliuca, et al. 2014. Generation of functional human pancreatic β cells in vitro. Cell 159:428-439.
Rhinn & Dolle. 2012. Retinoic acid signaling during development. Development. 139: 843-858.
Fraichard, et al. 1995. In vitro differentiation of embryonic stem cells into glial cells and functional neurons. J of Cell Science. 108: 3181-3188.

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