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Z-VAD-FMK

Z-VAD-FMK is a cell-permeable, irreversible pan-caspase inhibitor. Inhibits caspase processing and apoptosis induction in tumor cells.

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SKU	SIZE	PRICE	QTY
SML18B	10 mg	$575.00	Qty - +

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Description

Specifications

More Information
SKU	SML18B
Size	10 mg
Molecular Name	Z-VAD-FMK
Form	Powder
Alternative Names	Z-Val-Ala-Asp(OMe)-FMK; Z-VAD(OMe)-FMK;
Chemical Name	L-Alaninamide, N-[(phenylmethoxy)carbonyl]-L-valyl-N-[(1S)-3-fluoro-1-(2-methoxy-2- oxoethyl)-2-oxopropyl]-
Chemical Formula	C₂₂H₃₀FN₃O₇
Molecular Weight	467.49
CAS Number	187389-52-2
Purity	≥98% by HPLC
Physical Appearance	White to off-white (Solid)
Target	Caspase
Shelf-Life	3 years
Shipping	Room Temperature
Storage	Powder: - 20°C for 3 years and 4°C for 2 years
Quality Statement	This product is for Research Use Only and is not intended for therapeutic or diagnostic use.

Z-VAD-FMK is a cell-permeable pan-caspase inhibitor that irreversibly binds to the catalytic site of caspase proteases and can inhibit induction of apoptosis. Z-VAD-FMK has been shown to block TGF-beta1-induced apoptosis and inhibit CPP32-like protease activity in lysates in the pretreatment of hepatocytes.

Features

Broad-spectrum caspase inhibitor
Potent inhibitor of caspase-dependent inflammasomes
Blocks the induction of apoptosis
Each lot is highly pure (≥95%) and functionally tested

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References and Publications

Kawasaki M, et al. (2000) Protection from lethal apoptosis in lipopolysaccharide-induced acute lung injury in mice by a caspase inhibitor. Am J Pathol. 157(2):597- 603.
Park S, et al. (2004) Neurovascular protection reduces early brain injury after subarachnoid hemorrhage. Stroke. 35(10):2412-7.
Inayat-Hussain SH, et al. (1997) Processing/activation of CPP32-like proteases is involved in transforming growth factor beta1-induced apoptosis in rat hepatocytes. Hepatology. 25(6):1516-26.

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