Neural

SB203580 is a selective ATP-competitive p38 MAPK inhibitor with IC50s of 50 nM and 500 nM for SAPK2a / p38 and SAPK2b / p38β2. Enhances the growth of mouse ES cells and enhances differentiation of cardiomyocytes from human ES cells.

SB431542 is a potent small molecule inhibitor of TGF-β signaling. Used for hESC neural differentiation and enhanced differentiation of PSCs into cardiomyocytes. Replaces SOX2 in reprogramming of fibroblasts into iPSCs.

Thiazovivin is a novel ROCK inhibitor with IC50 of 0.5 μM in a cell-free assay, promotes hESC survival after single-cell dissociation. Improves the efficiency of fibroblast reprogramming and induction of iPSCs.

An integrated stress response (ISR) inhibitor that promotes survival of pluripotent stem cells in culture when used in combination with Chroman 1 and Emricasan small molecules in the CEPT cocktail¹.
Size: 10 mg

XAV939 is a potent tankyrase (TNKS) inhibitor. Promotes cardiomyocyte differentiation in mesoderm progenitor cells. Also used in neuronal differentiation protocols.

Y-27632 is a cell-permeable, highly potent and selective inhibitor of Rho-associated, coiled-coil containing protein kinase (ROCK). Increases survival rate of human embryonic stem (hES) cells and iPSC undergoing cryopreservation. Used to reprogram fibroblasts to mature neurons and used as component of growth media for urothelial organoids.