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Mesenchymal

Mesenchymal

Mesenchymal stem cells (MSCs) are multipotent stem cells that can differentiate into a variety of cell types, including bone cells (osteoblasts), cartilage cells (chondrocytes), muscle cells (myocytes) and fat cells that give rise to marrow adipose tissue (adipocytes). MSCs are among the most frequently used cell type for regenerative medicine including COVID-19, diabetes research, tissue engineering, and bone and cartilage diseases.

Explore our portfolio of products to support your MSC culture workflow.

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  1. A83-01
    A83-01
    A83-01 s a potent inhibitor of TGF-β type I receptor ALK5 kinase, type I activin/nodal receptor. A83-01 molecule facilitates stem cell reprogramming and differentiation of hPSCs. A83-01 is supplied as a lyophilized powder.
  2. Accutase
    Accutase
    Accutase® Cell Detachment Solution is a ready-to-use liquid consisting of a proprietary mixture of proteolytic and collagenolytic enzymes for use in dissociation of cells from standard and adhesion-coated plasticware. Ideal replacement for trypsin and for use with stem cells including MSCs and hPSCs.
  3. BIRB796 (Doramapimod)
    BIRB796 (Doramapimod)
    BIRB796 is a highly potent inhibitor of p38 MAPK that enhances stem cell activity of cultured umbilical cord blood-derived hematopoietic cells. BIRB796 can be used in protocols for the chemical reprogramming of somatic cells to iPSCs.
  4. CHIR99021 Small Molecule
    CHIR99021
    CHIR99201 potentiates self-renewal of human and mouse embryonic stem cells and enhances reprogramming of somatic cells into stem cells. CHIR99201 also augments the differentiation potential of mesenchymal stem cells.
  5. ELAREM™ Ultimate-FDi
    ELAREM™ Ultimate-FDi
    ELAREM™ Ultimate-FDi is a virus-inactivated and fibrinogen-depleted human platelet lysate. Ultimate-FDi is a clinical-grade supplement suited for therapeutic cell manufacturing requiring gamma-irradiation and viral panel testing. GMP-grade, Drug Master File, and US origin.
  6. IWP-2 Small Molecule
    IWP-2
    IWP 2 is a potent inhibitor of Wnt processing and secretion (IC50 = 27nM). IWP 2 inactivates PORCN, a membrane-bound O-acyltransferase (MBOAT), and selectively inhibits palmitoylation of Wnt. IWP-2 has also been used in protocols to reprogram somatic cells to chemically-induced PSCs.
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